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Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis

The membrane serine protease matriptase is required for epidermal barrier function, hair formation, and thymocyte development in mice, and dysregulated matriptase expression causes epidermal squamous cell carcinoma. To elucidate the specific functions of matriptase in normal and aberrant epidermal d...

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Autori principali: List, Karin, Szabo, Roman, Molinolo, Alfredo, Nielsen, Boye Schnack, Bugge, Thomas H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606590/
https://ncbi.nlm.nih.gov/pubmed/16651618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051071
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