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Cell-Cycle Markers in a Transgenic Mouse Model of Human Tauopathy : Increased Levels of Cyclin-Dependent Kinase Inhibitors p21Cip1 and p27Kip1

Recent evidence has suggested that an abnormal reactivation of the cell cycle may precede and cause the hyperphosphorylation and filament formation of tau protein in Alzheimer’s disease and other tauopathies. Here we have analyzed the expression and/or activation of proteins involved in cell-cycle p...

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Autores principales: Delobel, Patrice, Lavenir, Isabelle, Ghetti, Bernardino, Holzer, Max, Goedert, Michel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606514/
https://ncbi.nlm.nih.gov/pubmed/16507903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050540
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