Age-Related Loss of Synaptophysin Immunoreactive Presynaptic Boutons within the Hippocampus of APP751(SL), PS1(M146L), and APP751(SL)/PS1(M146L) Transgenic Mice

Neuron and synapse loss are important features of the neuropathology of Alzheimer’s disease (AD). Recently, we observed substantial age-related hippocampal neuron loss in APP751(SL)/PS1(M146L) transgenic mice but not in PS1(M146L) mice. Here, we investigated APP751(SL) mice, PS1(M146L) mice, and APP...

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Hauptverfasser: Rutten, Bart P.F., Van der Kolk, Nicolien M., Schafer, Stephanie, van Zandvoort, Marc A.M.J., Bayer, Thomas A., Steinbusch, Harry W.M., Schmitz, Christoph
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2005
Schlagworte:
Original Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1603440/
https://ncbi.nlm.nih.gov/pubmed/15972962
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