Developmental Abnormalities of Neuronal Structure and Function in Prenatal Mice Lacking the Prader-Willi Syndrome Gene Necdin

Necdin (Ndn) is one of a cluster of genes deleted in the neurodevelopmental disorder Prader-Willi syndrome (PWS). Ndn(tm2Stw) mutant mice die shortly after birth because of abnormal respiratory rhythmogenesis generated by a key medullary nucleus, the pre-Bötzinger complex (preBötC). Here, we address...

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Main Authors: Pagliardini, Silvia, Ren, Jun, Wevrick, Rachel, Greer, John J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2005
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Original Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1603432/
https://ncbi.nlm.nih.gov/pubmed/15972963
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