The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways

In Prader-Willi syndrome (PWS), obesity is caused by the disruption of appetite-controlling pathways in the brain. Two PWS candidate genes encode MAGEL2 and necdin, related melanoma antigen proteins that assemble into ubiquitination complexes. Mice lacking Magel2 are obese and lack leptin sensitivit...

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Publicado no:Hum Mol Genet
Main Authors: Wijesuriya, Tishani Methsala, De Ceuninck, Leentje, Masschaele, Delphine, Sanderson, Matthea R, Carias, Karin Vanessa, Tavernier, Jan, Wevrick, Rachel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886282/
https://ncbi.nlm.nih.gov/pubmed/28973533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx311
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