Elevated Endothelial Nitric Oxide Bioactivity and Resistance to Angiotensin-Dependent Hypertension in 12/15-Lipoxygenase Knockout Mice

12/15-Lipoxygenase (12/15-LOX) plays a pathogenic role in atherosclerosis. To characterize whether 12/15-LOX also contributes to endothelial dysfunction and hypertension, regulation of vessel tone and angiotensin II (ang II) responses were characterized in mice deficient in 12/15-LOX. There was a tw...

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Detalhes bibliográficos
Main Authors: Anning, Peter B., Coles, Barbara, Bermudez-Fajardo, Alexandra, Martin, Patricia E.M., Levison, Bruce S., Hazen, Stanley L., Funk, Colin D., Kühn, Hartmut, O’Donnell, Valerie B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2005
Assuntos:
Original Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602346/
https://ncbi.nlm.nih.gov/pubmed/15743778
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