p53-Induced Apoptosis Occurs in the Absence of p14(ARF) in Malignant Pleural Mesothelioma

Malignant pleural mesotheliomas (MPMs) are usually wild type for the p53 gene but contain homozygous deletions in the INK4A locus that encodes p14(ARF), an inhibitor of p53-MDM2 interaction. Previous findings suggest that lack of p14(ARF) expression and the presence of SV40 large T antigen (L-Tag) r...

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Detalhes bibliográficos
Main Authors: Hopkins-Donaldson, Sally, Belyanskaya, Larisa L, Simões-Wüst, Ana Paula, Sigrist, Brigitte, Kurtz, Stefanie, Zangemeister-Wittke, Uwe, Stahel, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1601933/
https://ncbi.nlm.nih.gov/pubmed/16867217
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