P14/ARF-Positive Malignant Pleural Mesothelioma: A Phenotype With Distinct Immune Microenvironment

INTRODUCTION: The CDKN2A gene plays a central role in the pathogenesis of malignant pleural mesothelioma (MPM). The gene encodes for two tumor suppressor proteins, p16/INK4A and p14/ARF, frequently lost in MPM tumors. The exact role of p14/ARF in MPM and overall its correlation with the immune micro...

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Foilsithe in:Front Oncol
Main Authors: Pezzuto, Federica, Lunardi, Francesca, Vedovelli, Luca, Fortarezza, Francesco, Urso, Loredana, Grosso, Federica, Ceresoli, Giovanni Luca, Kern, Izidor, Vlacic, Gregor, Faccioli, Eleonora, Schiavon, Marco, Gregori, Dario, Rea, Federico, Pasello, Giulia, Calabrese, Fiorella
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2021
Ábhair:
Oncology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8019896/
https://ncbi.nlm.nih.gov/pubmed/33828993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.653497
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