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Dominant negative down-regulation of endotoxin-induced tumor necrosis factor α production by Lps(d)/Ran

We recently showed that adenoviral transfer and expression of the Lps(d)/Ran gene isolated from endotoxin-resistant C3H/HeJ mice could protect endotoxin-sensitive mice from endotoxic shock. Elevation of proinflammatory cytokines, such as tumor necrosis factor α (TNF-α), is thought to be essential fo...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Yuan, Quan, Zhao, Fangping, Chung, Siu-Wah, Fan, Peidong, Sultzer, Barnet M., Kan, Y. W., Wong, Peter M. C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16019/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10706609/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040567797
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