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Combined Analysis of COX-2 and p53 Expressions Reveals Synergistic Inverse Correlations with Microsatellite Instability and CpG Island Methylator Phenotype in Colorectal Cancer

Cyclooxygenase-2 (COX-2) overexpression and mutations of p53 (a known COX-2 regulator) are inversely associated with microsatellite instability—high (MSI-H) and CpG island methylator phenotype (CIMP), characterized by extensive promoter methylation, is associated with MSI-H. However, no studies have...

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Bibliografiske detaljer
Main Authors: Ogino, Shuji, Brahmandam, Mohan, Kawasaki, Takako, Kirkner, Gregory J, Loda, Massimo, Fuchs, Charles S
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1601473/
https://ncbi.nlm.nih.gov/pubmed/16820091
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