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Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes

Signaling mediated by the mammalian target of rapamycin kinase (mTOR) is activated during human cytomegalovirus (HCMV) infection. mTOR is found in two complexes differing by the binding partner, rictor or raptor. Activated mTOR-raptor promotes cap-dependent translation through the hyperphosphorylati...

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Autors principals: Kudchodkar, Sagar B., Yu, Yongjun, Maguire, Tobi G., Alwine, James C.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599931/
https://ncbi.nlm.nih.gov/pubmed/16959881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605825103
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