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Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4(+) T cells

Multiple myelomas produce tumor-specific antigen (TSA) in the form of idiotype (Id) on monoclonal Ig. CD4(+) T cells can recognize Id-peptide on MHC class II molecules and protect against challenges with MOPC315 cells, which are, as common for myelomas, class II-negative. The present study explains...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Dembic, Zlatko, Schenck, Karl, Bogen, Bjarne
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15992/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10706628/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.050579897
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