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A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics

Novel chemotherapeutics with marked and selective antitumor activity are essential to develop, particularly those that can overcome resistance to established therapies. Iron (Fe) is critical for cell-cycle progression and DNA synthesis and potentially represents a novel molecular target for the desi...

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Autori principali: Whitnall, Megan, Howard, Jonathan, Ponka, Prem, Richardson, Des R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1595448/
https://ncbi.nlm.nih.gov/pubmed/17003122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604979103
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