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A Mycothiol Synthase Mutant of Mycobacterium tuberculosis Has an Altered Thiol-Disulfide Content and Limited Tolerance to Stress

Mycothiol (MSH) (acetyl-Cys-GlcN-Ins) is the major low-molecular-mass thiol in Mycobacterium tuberculosis. MSH has antioxidant activity, can detoxify a variety of toxic compounds, and helps to maintain the reducing environment of the cell. The production of MSH provides a potential novel target for...

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Main Authors: Buchmeier, Nancy A., Newton, Gerald L., Fahey, Robert C.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1595396/
https://ncbi.nlm.nih.gov/pubmed/16923891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00393-06
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