Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

The 3D structures of human therapeutic targets are enabling for drug discovery. However, their purification and crystallization remain rate determining. In individual cases, ligands have been used to increase the success rate of protein purification and crystallization, but the broad applicability o...

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Bibliografische gegevens
Hoofdauteurs: Vedadi, Masoud, Niesen, Frank H., Allali-Hassani, Abdellah, Fedorov, Oleg Y., Finerty, Patrick J., Wasney, Gregory A., Yeung, Ron, Arrowsmith, Cheryl, Ball, Linda J., Berglund, Helena, Hui, Raymond, Marsden, Brian D., Nordlund, Pär, Sundstrom, Michael, Weigelt, Johan, Edwards, Aled M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2006
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1595307/
https://ncbi.nlm.nih.gov/pubmed/17035505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605224103
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