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Control of Borrelia burgdorferi-Specific CD4(+)-T-Cell Effector Function by Interleukin-12- and T-Cell Receptor-Induced p38 Mitogen-Activated Protein Kinase Activity

Infection with Borrelia burgdorferi, the causative agent of Lyme disease, results in a Th1 response and proinflammatory cytokine production. Mice deficient for MKK3, an upstream activator of p38 mitogen-activated protein (MAP) kinase, develop a lower Th1 response and exhibit an impaired ability to p...

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Библиографические подробности
Главные авторы: Hedrick, Michael N., Olson, Chris M., Conze, Dietrich B., Bates, Tonya C., Rincón, Mercedes, Anguita, Juan
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1594917/
https://ncbi.nlm.nih.gov/pubmed/16988247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00623-06
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