p38 Mitogen-Activated Protein Kinase Controls NF-κB Transcriptional Activation and Tumor Necrosis Factor Alpha Production through RelA Phosphorylation Mediated by Mitogen- and Stress-Activated Protein Kinase 1 in Response to Borrelia burgdorferi Antigens

The interaction of Borrelia burgdorferi, the causative agent of Lyme borreliosis, with phagocytic cells induces the activation of NF-κB and the expression of proinflammatory cytokines including tumor necrosis factor alpha (TNF-α). B. burgdorferi-induced TNF-α production is also dependent on the acti...

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Detalhes bibliográficos
Main Authors: Olson, Chris M., Hedrick, Michael N., Izadi, Hooman, Bates, Tonya C., Olivera, Elias R., Anguita, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828394/
https://ncbi.nlm.nih.gov/pubmed/17074860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01412-06
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