Hyperplasia and Spontaneous Tumor Development in the Gynecologic System in Mice Lacking the BRCA1-Δ11 Isoform

Alternative splicing in the BRCA1 locus generates multiple protein products including BRCA1-Δ11, which is identical to the BRCA1 full-length isoform (BRCA1-FL) except for the absence of exon 11. Mutation analysis using gene targeting to create null mutations or disrupt BRCA-FL has provided much of o...

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Bibliographic Details
Main Authors: Kim, Sang Soo, Cao, Liu, Lim, Sung-Chul, Li, Cuiling, Wang, Rui-Hong, Xu, Xiaoling, Bachelier, Richard, Deng, Chu-Xia
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592852/
https://ncbi.nlm.nih.gov/pubmed/16943438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00796-06
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