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Binding of SH2-B Family Members within a Potential Negative Regulatory Region Maintains JAK2 in an Active State
The tyrosine kinase Janus kinase 2 (JAK2) transduces signaling for the majority of known cytokine receptor family members and is constitutively activated in some cancers. Here we examine the mechanisms by which the adapter proteins SH2-Bβ and APS regulate the activity of JAK2. We show that like SH2-...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1592834/ https://ncbi.nlm.nih.gov/pubmed/16914724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00570-06 |
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