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Complex Minisatellite Rearrangements Generated in the Total or Partial Absence of Rad27/hFEN1 Activity Occur in a Single Generation and Are Rad51 and Rad52 Dependent

Genomes contain tandem repeat blocks that are at risk of expansion or contraction. The mechanisms of destabilization of the human minisatellite CEB1 (arrays of 36- to 43-bp repeats) were investigated in a previously developed model system, in which CEB1-0.6 (14 repeats) and CEB1-1.8 (42 repeats) all...

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Autors principals: Lopes, Judith, Ribeyre, Cyril, Nicolas, Alain
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592832/
https://ncbi.nlm.nih.gov/pubmed/16914748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00649-06
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