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Complex Minisatellite Rearrangements Generated in the Total or Partial Absence of Rad27/hFEN1 Activity Occur in a Single Generation and Are Rad51 and Rad52 Dependent

Genomes contain tandem repeat blocks that are at risk of expansion or contraction. The mechanisms of destabilization of the human minisatellite CEB1 (arrays of 36- to 43-bp repeats) were investigated in a previously developed model system, in which CEB1-0.6 (14 repeats) and CEB1-1.8 (42 repeats) all...

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Detalhes bibliográficos
Main Authors: Lopes, Judith, Ribeyre, Cyril, Nicolas, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592832/
https://ncbi.nlm.nih.gov/pubmed/16914748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00649-06
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