Critical Role for a Single Leucine Residue in Leukemia Induction by E2A-PBX1

In roughly 5% of cases of acute lymphoblastic leukemia, a chromosomal translocation leads to expression of the oncogenic protein E2A-PBX1. The N-terminal portion of E2A-PBX1, encoded by the E2A gene, is identical in sequence to the corresponding portion of the E proteins E12/E47 and includes transcr...

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Autors principals: Bayly, Richard, Murase, Takayuki, Hyndman, Brandy D., Savage, Rachel, Nurmohamed, Salima, Munro, Kim, Casselman, Richard, Smith, Steven P., LeBrun, David P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592826/
https://ncbi.nlm.nih.gov/pubmed/16914730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02025-05
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