Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells

The HOX genes encode a family of transcription factors that have key roles in both development and malignancy. Disrupting the interaction between HOX proteins and their binding partner, PBX, has been shown to cause apoptotic cell death in a range of solid tumors. However, despite HOX proteins playin...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Alharbi, Raed A., Pandha, Hardev S., Simpson, Guy R., Pettengell, Ruth, Poterlowicz, Krzysztof, Thompson, Alexander, Harrington, Kevin, El-Tanani, Mohamed, Morgan, Richard
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2017
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685692/
https://ncbi.nlm.nih.gov/pubmed/29163771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20023
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