Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells

The HOX genes encode a family of transcription factors that have key roles in both development and malignancy. Disrupting the interaction between HOX proteins and their binding partner, PBX, has been shown to cause apoptotic cell death in a range of solid tumors. However, despite HOX proteins playin...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Alharbi, Raed A., Pandha, Hardev S., Simpson, Guy R., Pettengell, Ruth, Poterlowicz, Krzysztof, Thompson, Alexander, Harrington, Kevin, El-Tanani, Mohamed, Morgan, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685692/
https://ncbi.nlm.nih.gov/pubmed/29163771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20023
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