Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells

The HOX genes encode a family of transcription factors that have key roles in both development and malignancy. Disrupting the interaction between HOX proteins and their binding partner, PBX, has been shown to cause apoptotic cell death in a range of solid tumors. However, despite HOX proteins playin...

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Vydáno v:Oncotarget
Hlavní autoři: Alharbi, Raed A., Pandha, Hardev S., Simpson, Guy R., Pettengell, Ruth, Poterlowicz, Krzysztof, Thompson, Alexander, Harrington, Kevin, El-Tanani, Mohamed, Morgan, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685692/
https://ncbi.nlm.nih.gov/pubmed/29163771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20023
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