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Fbxw8 Is Essential for Cul1-Cul7 Complex Formation and for Placental Development
Cullin-based ubiquitin ligases (E3s) constitute one of the largest E3 families. Fbxw8 (also known as Fbw6 or Fbx29) is an F-box protein that is assembled with Cul7 in an SCF-like E3 complex. Here we show that Cul7 forms a heterodimeric complex with Cul1 in a manner dependent on Fbxw8. We generated m...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1592786/ https://ncbi.nlm.nih.gov/pubmed/16880526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00595-06 |
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