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Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene

Choline is an important methyl donor and a component of membrane phospholipids. In this study, we tested the hypothesis that choline availability can modulate cell proliferation and the methylation of genes that regulate cell cycling. In several other model systems, hypomethylation of cytosine bases...

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Bibliografiske detaljer
Main Authors: Niculescu, Mihai D., Yamamuro, Yutaka, Zeisel, Steven H.
Format: Artigo
Sprog:Inglês
Udgivet: 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592524/
https://ncbi.nlm.nih.gov/pubmed/15147518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2004.02414.x
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