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Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene

Maternal choline availability is essential for fetal neurogenesis. Choline deprivation (CD) causes hypomethylation of specific CpG islands in genes controlling cell cycling in fetal hippocampus. We now report that, in C57BL/6 mice, CD during gestational days 12–17 also altered methylation of the his...

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Main Authors: Mehedint, Mihai G., Niculescu, Mihai D., Craciunescu, Corneliu N., Zeisel, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado: The Federation of American Societies for Experimental Biology 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797040/
https://ncbi.nlm.nih.gov/pubmed/19752176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-140145
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