Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase

Methylation of CpG dinucleotides is the major epigenetic modification of mammalian genomes, critical for regulating chromatin structure and gene activity. The mixed-lineage leukaemia (MLL) CXXC domain selectively binds nonmethyl-CpG DNA, and is required for transformation by MLL fusion proteins that...

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Autori principali: Allen, Mark D, Grummitt, Charles G, Hilcenko, Christine, Min, Sandra Young, Tonkin, Louise M, Johnson, Christopher M, Freund, Stefan M, Bycroft, Mark, Warren, Alan J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1589984/
https://ncbi.nlm.nih.gov/pubmed/16990798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601340
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