GLI3 mutations in human disorders mimic Drosophila Cubitus interruptus protein functions and localization

Truncation mutations of the GLI3 zinc finger transcription factor can cause Greig cephalopolysyndactyly syndrome (GCPS), Pallister–Hall syndrome (PHS), and postaxial polydactyly type A (PAP-A). GLI3 is homologous to Drosophila Cubitus interruptus (Ci), which regulates the patched (ptc), gooseberry (...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shin, Sang Hoon, Kogerman, Priit, Lindström, Erika, Toftgárd, Rune, Biesecker, Leslie G.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15863/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10077605/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.6.2880
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