Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome

We have previously demonstrated that PM-Scl-75, a component of the human exosome complex involved in RNA maturation and mRNA decay, can specifically interact with RNAs containing an AU-rich instability element. Through the analysis of a series of deletion mutants, we have now shown that a 266 amino...

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Detalhes bibliográficos
Main Authors: Anderson, John R., Mukherjee, Devi, Muthukumaraswamy, Karthika, Moraes, Karen C.M., Wilusz, Carol J., Wilusz, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1581985/
https://ncbi.nlm.nih.gov/pubmed/16912217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.144606
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