Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo

Acute T cell–mediated diarrhea is associated with increased mucosal expression of proinflammatory cytokines, including the TNF superfamily members TNF and LIGHT. While we have previously shown that epithelial barrier dysfunction induced by myosin light chain kinase (MLCK) is required for the develop...

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Autores principales: Clayburgh, Daniel R., Musch, Mark W., Leitges, Michael, Fu, Yang-Xin, Turner, Jerrold R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2006
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1578628/
https://ncbi.nlm.nih.gov/pubmed/17016558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29218
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