Epithelial myosin light chain kinase–dependent barrier dysfunction mediates T cell activation–induced diarrhea in vivo

Disruption of the intestinal epithelial barrier occurs in many intestinal diseases, but neither the mechanisms nor the contribution of barrier dysfunction to disease pathogenesis have been defined. We utilized a murine model of T cell–mediated acute diarrhea to investigate the role of the epithelial...

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Detalhes bibliográficos
Principais autores: Clayburgh, Daniel R., Barrett, Terrence A., Tang, Yueming, Meddings, Jon B., Van Eldik, Linda J., Watterson, D. Martin, Clarke, Lane L., Mrsny, Randall J., Turner, Jerrold R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224297/
https://ncbi.nlm.nih.gov/pubmed/16184195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24970
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