Targeted Apoptosis Activation with GrB/scFvMEL Modulates Melanoma Growth, Metastatic Spread, Chemosensitivity, and Radiosensitivity

GrB/scFvMEL, a fusion protein composed of human granzyme B (GrB) and the single-chain antibody scFvMEL, targets melanoma gp240 antigen and exerts impressive cytotoxic effects by inducing apoptosis. We evaluated the effects of GrB/scFvMEL on chemotherapy, radiation therapy, metastasis in vitro, and t...

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Detalhes bibliográficos
Main Authors: Liu, Yuying, Zhang, Weihe, Niu, Ting, Cheung, Lawrence H, Munshi, Anupama, Meyn, Raymond E, Rosenblum, Michael G
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1578517/
https://ncbi.nlm.nih.gov/pubmed/16611405
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