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Biphasic Modulation of Ryanodine Receptors by Sulfhydryl Oxidation in Rat Ventricular Myocytes

To understand better the modulation of ryanodine receptors (RyRs) during oxidative stress, the effect of 4,4′-dithiodipyridine (DTDP), a cell-permeant and thiol-reactive oxidant, on global Ca(2+) signal and spontaneous Ca(2+) sparks of rat ventricular myocytes was investigated. It was shown that a b...

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Autori principali: Xie, Hong, Zhu, Pei-Hong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biophysical Society 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1578479/
https://ncbi.nlm.nih.gov/pubmed/16877504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.087338
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