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Two Rings of Negative Charges in the Cytosolic Vestibule of Type-1 Ryanodine Receptor Modulate Ion Fluxes

The tetrameric ryanodine receptor calcium release channels (RyRs) are cation-selective channels that have pore architecture similar to that of K(+) channels. We recently identified, in close proximity to the selectivity filter motif GGGIG, a conserved lumenal DE motif that has a critical role in RyR...

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Autores principales: Xu, Le, Wang, Ying, Gillespie, Dirk, Meissner, Gerhard
Formato: Artigo
Lenguaje:Inglês
Publicado: Biophysical Society 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367051/
https://ncbi.nlm.nih.gov/pubmed/16239337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.072538
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