Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro

Acidification of the extracellular milieu of malignant tumors is reported to increase the invasive behavior of cancer cells. In normal tissues, production of acid is catalyzed by carbonic anhydrases (CAs), some of which are known to be overexpressed in certain cancers. To investigate the functional...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Parkkila, Seppo, Rajaniemi, Hannu, Parkkila, Anna-Kaisa, Kivelä, Jyrki, Waheed, Abdul, Pastoreková, Silvia, Pastorek, Jaromir, Sly, William S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15781/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688890/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040554897
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