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Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro

Acidification of the extracellular milieu of malignant tumors is reported to increase the invasive behavior of cancer cells. In normal tissues, production of acid is catalyzed by carbonic anhydrases (CAs), some of which are known to be overexpressed in certain cancers. To investigate the functional...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Parkkila, Seppo, Rajaniemi, Hannu, Parkkila, Anna-Kaisa, Kivelä, Jyrki, Waheed, Abdul, Pastoreková, Silvia, Pastorek, Jaromir, Sly, William S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2000
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15781/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688890/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040554897
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