Tramadol produces outward currents by activating μ-opioid receptors in adult rat substantia gelatinosa neurones

1. An action of a tramadol metabolite, mono-O-dimethyl-tramadol (M1), on substantia gelatinosa (SG) neurones in adult rat spinal cord slices was examined by using the whole-cell patch-clamp technique. 2. In 41% of the neurones examined, superfusing M1 produced an outward current at −70 mV; this resp...

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Bibliografiske detaljer
Main Authors: Koga, Akiko, Fujita, Tsugumi, Totoki, Tadahide, Kumamoto, Eiichi
Format: Artigo
Sprog:Inglês
Udgivet: 2005
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Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576176/
https://ncbi.nlm.nih.gov/pubmed/15834442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706225
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