Inhibition by O-desmethyltramadol of glutamatergic excitatory transmission in adult rat spinal substantia gelatinosa neurons

To reveal cellular mechanisms for antinociception produced by clinically used tramadol, we investigated the effect of its metabolite O-desmethyltramadol (M1) on glutamatergic excitatory transmission in spinal dorsal horn lamina II (substantia gelatinosa; SG) neurons. The whole-cell patch-clamp techn...

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Detalles Bibliográficos
Publicado en:Mol Pain
Main Authors: Koga, Akiko, Fujita, Tsugumi, Piao, Lian-Hua, Nakatsuka, Terumasa, Kumamoto, Eiichi
Formato: Artigo
Idioma:Inglês
Publicado: SAGE Publications 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348506/
https://ncbi.nlm.nih.gov/pubmed/30799694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806918824243
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