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Effect of mast cell chymase inhibitor on the development of scleroderma in tight-skin mice

1. Although the pathogenesis of scleroderma is not fully understood, activation of connective-tissue-type mast cells (CTMCs) has been implicated in various fibrotic diseases. 2. Our previous study showed that the number of CTMCs was markedly increased during fibrous proliferation in the skin of a sc...

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Autori principali: Shiota, Naotaka, Kakizoe, Eiichi, Shimoura, Keiko, Tanaka, Tetsuya, Okunishi, Hideki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576161/
https://ncbi.nlm.nih.gov/pubmed/15806109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706209
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