Insights into the functional roles of α(1)-adrenoceptor subtypes in mouse carotid arteries using knockout mice

1. α(1)-Adrenoceptor (AR) subtypes in mouse carotid arteries were characterised using a combination of agonist/antagonist pharmacology and knockout (KO) mice. 2. Phenylephrine (PE) was most potent in the α(1B)-KO (pEC(50)=6.9±0.2) followed by control (pEC(50)=6.3±0.06) and α(1D)-KO (pEC(50)=5.5±0.07...

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Main Authors: Deighan, Clare, Methven, Laura, Naghadeh, Mustafa M, Wokoma, Alexis, Macmillan, Joyce, Daly, Craig J, Tanoue, Akito, Tsujimoto, Gozoh, McGrath, John C
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576034/
https://ncbi.nlm.nih.gov/pubmed/15655508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706089
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