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Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors

1. Co-administration of the calcineurin inhibitor cyclosporine and the mTOR inhibitors sirolimus or everolimus increases the efficacy of immunosuppression after organ transplantation. However, clinical studies showed enhancement of cyclosporine toxicity. To characterize the biochemical mechanisms in...

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Détails bibliographiques
Auteurs principaux: Christians, Uwe, Gottschalk, Sven, Miljus, Jelena, Hainz, Carsten, Benet, Leslie Z, Leibfritz, Dieter, Serkova, Natalie
Format: Artigo
Langue:Inglês
Publié: 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575349/
https://ncbi.nlm.nih.gov/pubmed/15339861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705939
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