Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors

1. Co-administration of the calcineurin inhibitor cyclosporine and the mTOR inhibitors sirolimus or everolimus increases the efficacy of immunosuppression after organ transplantation. However, clinical studies showed enhancement of cyclosporine toxicity. To characterize the biochemical mechanisms in...

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Bibliographic Details
Main Authors: Christians, Uwe, Gottschalk, Sven, Miljus, Jelena, Hainz, Carsten, Benet, Leslie Z, Leibfritz, Dieter, Serkova, Natalie
Format: Artigo
Language:Inglês
Published: 2004
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575349/
https://ncbi.nlm.nih.gov/pubmed/15339861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705939
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