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Differential modulation of Na(v)1.7 and Na(v)1.8 peripheral nerve sodium channels by the local anesthetic lidocaine

1. Voltage-gated Na(+) channels are transmembrane proteins that are essential for the propagation of action potentials in excitable cells. Na(v)1.7 and Na(v)1.8 dorsal root ganglion Na(+) channels exhibit different kinetics and sensitivities to tetrodotoxin (TTX). We investigated the properties of b...

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Detalhes bibliográficos
Main Authors: Chevrier, P, Vijayaragavan, K, Chahine, M
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574965/
https://ncbi.nlm.nih.gov/pubmed/15148257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705796
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