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Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice

1. We previously reported that acute incubation with tetrahydrobiopterin (BH(4)) or sepiapterin, a cofactor for endothelial nitric oxide synthase and a stable precursor of BH(4), respectively, enhanced the acetylcholine (Ach)-induced relaxation of isolated small mesenteric arteries (SMA) from diabet...

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Библиографические подробности
Главные авторы: Pannirselvam, Malarvannan, Simon, Valerie, Verma, Subodh, Anderson, Todd, Triggle, Chris R
Формат: Artigo
Язык:Inglês
Опубликовано: 2003
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574066/
https://ncbi.nlm.nih.gov/pubmed/14534153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705476
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