Partial agonist behaviour depends upon the level of nociceptin/orphanin FQ receptor expression: studies using the ecdysone-inducible mammalian expression system

1. Partial agonism is primarily dependent upon receptor density and coupling efficiency. As these parameters are tissue/model dependent, intrinsic activity in different tissues can vary. We have utilised the ecdysone-inducible expression system containing the human nociceptin/orphanin FQ (N/OFQ) pep...

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Hlavní autoři: McDonald, J, Barnes, T A, Okawa, H, Williams, J, Calo', G, Rowbotham, D J, Lambert, D G
Médium: Artigo
Jazyk:Inglês
Vydáno: 2003
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Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573999/
https://ncbi.nlm.nih.gov/pubmed/12967935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705401
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