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Despite increased plasma concentration, inflammation reduces potency of calcium channel antagonists due to lower binding to the rat heart
1. Rheumatoid arthritis reduces verapamil oral clearance thereby increases plasma concentration of the drug. This coincides with reduced drug effects through an unknown mechanism. 2. The effect of interferon-induced acute inflammation on the pharmacokinetics and electrocardiogram of verapamil (20 mg...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573909/ https://ncbi.nlm.nih.gov/pubmed/12839868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705202 |
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