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Drug-disease interactions: reduced β-adrenergic and potassium channel antagonist activities of sotalol in the presence of acute and chronic inflammatory conditions in the rat
1. Inflammation may influence response to pharmacotherapy. 2. We investigated the effect of inflammation on response to sotalol, a β-adrenergic receptor and potassium channel antagonist. Racemic sotalol (40 mg kg(−1)) was administered to healthy, acutely (interferonα 2a-induced) and chronically (Myc...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572777/ https://ncbi.nlm.nih.gov/pubmed/11350865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704067 |
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