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Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers

BACKGROUND AND PURPOSE: Inflammation elevates plasma verapamil concentrations but diminishes pharmacological response. Angiotensin II is a pro-inflammatory mediator. We examined the effect of angiotensin II receptor blockade on the pharmacokinetics and pharmacodynamics of verapamil, as well as the b...

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Detalhes bibliográficos
Main Authors: Hanafy, S, Dagenais, N J, Dryden, W F, Jamali, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199397/
https://ncbi.nlm.nih.gov/pubmed/17965735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707538
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