Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

We have identified 2-methyl-6-(2-phenylethenyl)pyridine (SIB-1893) and 2-methyl-6-phenylethynyl pyridine hydrochloride (MPEP) as positive allosteric modulators for the hmGluR4. SIB-1893 and MPEP enhanced the potency and efficacy of L-2-amino-4-phophonobutyrate (L-AP4) in guanosine 5′-O-(3-[(35)S]thi...

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Bibliografske podrobnosti
Main Authors: Mathiesen, Jesper Mosolff, Svendsen, Nannette, Bräuner-Osborne, Hans, Thomsen, Christian, Ramirez, M Teresa
Format: Artigo
Jezik:Inglês
Izdano: 2003
Teme:
Special Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573757/
https://ncbi.nlm.nih.gov/pubmed/12684257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705159
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