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The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia
1. The human HERG gene encodes the cardiac repolarizing K(+) current I(Kr) and is genetically inactivated in inherited long QT syndrome 2 (LQTS2). The antihistamine terfenadine blocks HERG channels, and can cause QT prolongation and torsades de pointes, whereas its carboxylate fexofenadine lacks HER...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2002
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573545/ https://ncbi.nlm.nih.gov/pubmed/12411421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704873 |
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